Rock Band

Rock Band allows gamers to perform music from the world's biggest rock artists with their friends as a virtual band using drum, bass/lead guitar and microphone peripherals, in addition to offering deep online connectivity. Built on unprecedented deals with the world's biggest record labels and music publishers, the music featured in Rock Band spans all genres of rock and includes many of the master recordings from the biggest songs and artists of all time.

Problems
It is not possible to use instruments in Rock Band 1, as it was made before Harmonix added support for GH/RB Wiimote guitar extensions. Actually the is no way to fix this, a patch is needed or a new hardware option that allows adding a USB passthrough in order for the game to recognize the instrument.