Xenoblade Chronicles

Xenoblade Chronicles, known in Japan as Xenoblade (ゼノブレイド, Zenobureido), is a console role-playing game published by Nintendo and developed by Monolith Soft for the Wii. With the Xeno series traditionally being a PlayStation exclusive, Xenoblade is the first of the series to make it to a Nintendo console. Originally not intended to be released in North America, a massive fan movement called Operation Rainfall convinced Nintendo to publish it in more regions.

The game follows a young man named Shulk, who wields the titular Xenoblade – an energy blade called the Monado – against the Mechon in order to ultimately save the world. The game world is designed to give the feeling of freedom and scope to the player; the environment is massive and most of it is available for exploration right from the start. Xenoblade uses a real time battle system, allowing the player to control his movement and attacks at will while party members attack automatically.

30 FPS Patch for PAL
There is a patch to make the PAL version run at 30 FPS rather than its default 25 FPS. This makes gameplay smoother and matches the original JAP version's 30 FPS. Download the patch here or here. You may wish to back up your original .iso game image before applying the patch.
 * NOTE: You should only apply this patch if you can maintain a stable 25 FPS.

XBox 360 Button Icons
A texture pack has been made to allow the user to replace all Wii button icons in the game with XBox 360 icons. The pack contains one NTSC pack and three different PAL XBox 360 button icon types. A forum post with pictures on the Xenoblade Dolphin forum thread can be found here. The file can be downloaded here. Be sure to install whichever pack to your Dolphin install directory. Also, you MUST click "Load Custom Textures" under the "Advanced" tab of the "Graphics" configuration window.

Audio
Xenoblade Chronicles is a very sound-intensive game, so the most common emulation problems relate to sound stutter, choppy voices during cutscenes, and random crackles and pops in the music and in menus. The sound issues occur for most whether using XAudio2 or DSound. Using the LLE sound plugin can help for some users. Others using HLE can try to disable idle skipping and enable accurate vbeam emulation. Some users have reported having no problems with audio using these settings.

The main factor for whether the sound will have issues is what build is being used. There are several special Dolphin builds made with hacks to fix the sound issues, as can be found in the official forum thread for the game, or xenoblade HLE audio hack fix