The Legend of Zelda: Twilight Princess (GC)

In The Legend of Zelda: Twilight Princess, the next chapter in The Legend of Zelda series, Link can transform into a wolf to scour the darkened land of Hyrule. With the help of Midna, a mysterious being, you must guide Link through hordes of foul creatures and challenging bosses using new moves and a new horseback combat system. Many puzzles stand between Link and the fulfillment of his quest, so you must sharpen your wits as you hunt for weapons and items.

The GameCube version isn't mirrored like the Wii version and has free camera control. The GameCube version lacks motion controls while the Wii version does not support the GameCube controller. Although it can be patched from 4:3 to 16:9, as detailed under section below, there's no native widescreen support, unlike the Wii version.

Hyrule Field Slow Down
As the player progress through the game, Hyrule Field will become progressively slower. To fix it, enable the "Hyrule Field Speed Hack" in the ISO properties (right click the game in the game list > Properties > Patches tab > Hyrule Field Speed Hack). The NA and EU releases had the patch added to their GameINIs in, then JP was added in.

Unfortunately, the hack will reduce the quality of the minimap, so be warned.

Minimap

 * On Direct3D api, minimap will have some noise artifacts if Anti-Aliasing, Anisotropic Filtering, or Texture Filtering are enabled. Disable all 3 in order to get "clean" map. For OpenGL, disable Anti-Aliasing.
 * The Hyrule Field Speed Hack can also cause issues with the minimap.

Sun Rays
Twilight Princess uses a ray effect at various points throughout the game, most notably at windows and the fountains. The effect is very easily broken. How it is broken depends on the backend used:
 * D3D - Anti-aliasing and an Internal Resolution above 1x Native damage the effect
 * OpenGL - The GLSL merge greatly improves the effect in OpenGL. It is now only affected by Anisotropic Filtering and an Internal Resolution above 1x Native.

Custom Textures Scent Bug
While using custom textures, scent trails seen by wolf link can disappear. This isn't an issue until the player has to navigate Snowpeak, so switching back to default textures for the time being can solve this one. This issue has had little testing, and may be texture pack specific. Currently fixed with Ishiiruka-Dolphin v510.

D3D Darkness
With the D3D graphics backend the lens flare from the sun is glitched. When looking at the sun through trees of buildings, part of the effect shows through, displaying a small lens flare and an overall darkening of the screen. Only the D3D backend has this problem, so use OpenGL to avoid it. See. Fixed by.

Sound Issues
Sound problems may occur with the DSP HLE audio plugin. To correct these problems, use DSP LLE, but this may cause lag. Fixed by.

16:9 Aspect Ratio Fix
The built-in Widescreen Hack causes clipping and reflection issues. The following AR codes work as a replacement, causing less issues. To avoid conflicts, make sure that Widescreen Hack is disabled while using these codes.

NTSC
0445391C 3FE38E39

NTSC-J
0444DA64 3FE38E39

PAL
044558DC 3FE38E39

Reduce Bloom Ghosting
Due to Dolphin's bloom issues in EFB to Texture and Hybrid EFB to Ram, a "ghost" image will appear around certain objects in areas with high amounts of bloom. To disable bloom completely, use an Action Replay code below. 

No Bloom Effects [Ralf] 04009650 4E800020

HD Texture Pack
Zelda Twilight Princess: HD Texture Pack forum thread